Beklo 25mg Tablet

Uses of Beklo 25mg Tablet

• Manage muscle spasms (painful muscle contractions)

How does Beklo 25mg Tablet work?

Beklo 25mg Tablet works by inhibiting the release of certain chemicals in the brain and spinal cord, which helps to relieve pain and improve muscle movement.

Side Effects of Beklo 25mg Tablet

• Common: Drowsiness, dizziness, muscle weakness, constipation.
• Others: Ringing in the ears, skin rashes, mood changes, confusion, nausea, vomiting, headache, painful urination.

Quick Suggestions:

• Take Beklo 25mg Tablet as instructed by your doctor.
• Drink an adequate amount of water to avoid stomach discomfort.
• Do not break, crush, or chew the tablet. Do not take in larger or smaller amounts than prescribed.
• Do not stop taking this medicine without consulting your doctor, as it may cause withdrawal symptoms such as hallucination, confusion, seizures (fits), etc.
• Avoid consumption of alcohol during treatment with this medicine as it may increase the risk of side effects such as dizziness, drowsiness, etc.

Indication of Beklo 25mg Tablet

Baclof is used to reduce and relieve muscle spasms associated with conditions such as cerebral palsy, multiple sclerosis, spinal cord injuries/diseases, and other nervous system disorders.

Pharmacology:

Baclofen inhibits both monosynaptic and polysynaptic reflexes at the spinal level by stimulating GABAB receptors, which inhibits the release of glutamate and aspartate. It may also produce CNS depression at intraspinal sites and exerts an antinociceptive effect.

Dosage & Administration of Beklo 25mg Tablet

• Adults & Children over 10 years: Start with 5 mg 3 times daily with or after food, gradually increasing. Maximum dose is 100 mg daily.
• Children under 10 years:
  • 12 months to 2 years: 10-20 mg daily
  • 2 to 6 years: 20-30 mg daily
  • 6 to 10 years: 30-60 mg daily

Interaction

• Increased sedation with CNS agents, alcohol, or synthetic opiates.
• Increased risk of respiratory depression.
• Antihypertensive treatment may require dosage adjustment.
• Potentiation with tricyclic antidepressants, leading to pronounced muscular hypotonia.
• Mental confusion and agitation with levodopa and carbidopa in Parkinson’s disease.
• Enhanced CNS depressant effects with MAO inhibitors.
• Synergistic effects with magnesium sulfate or other neuromuscular blocking agents.

Contraindications

Hypersensitivity to any component of Baclofen.

Pregnancy & Lactation

• Pregnancy Category B3: Use only if potential benefits outweigh possible hazards.
• Lactation: Excreted in breast milk but considered safe in small quantities.

Precautions & Warnings

• Lower doses for patients with impaired renal function or on chronic hemodialysis.
• Use cautiously in patients with psychotic disorders, epilepsy, peptic ulcers, cerebrovascular diseases, or hepatic/renal/respiratory failure.
• Monitor respiratory and cardiovascular function in cardiopulmonary disease.
• Neurogenic bladder disturbances may improve; monitor for acute urine retention in sphincter hypertonia.
• Patients with stroke show poor tolerance and benefit.
• Perform periodic laboratory tests in hepatic diseases or diabetes mellitus.

Storage Conditions:

• Store below 30°C, away from light and moisture.
• Keep out of reach of children.